Tumorsuppressor相关论文
肾母细胞瘤(n WT)n 1基因位于人类染色体11p13，其编码的WT1具有抑制肿瘤生长与激活癌基因转录的双重功能，是一个双向转录因......
Somatic mutations of the chromatin remodeling gene ARID2 are observed in ～7% of human lung adenocarcinomas (LUADs). Howev......
Recent advances highlighted profound roles of FOXO transcription factors especially FOXO1 in bone development and remode......
Osteosarcoma is the most common cancer in bone,mainly arising from the metaphysis of the long bones.MicroRNA(miR)-200b h......
Objective Historical focus on protein-coding genes in disease pathology is due to the lack of sufficient awareness to id......
BAP1 Functions as A Tumor Suppressor in Hepatocellular Carcinoma by Deubiquitinating and Stabilizing
Objective Hepatocellular carcinoma(HCC)is the third most lethal cancer,with increasing incidence and mortality worldwide......
Human tumor suppressor hTid1-S,regulates AMPK/mTOR signaling to suppress clear cell renal cell carci
Renal cell carcinoma(RCC)is the most common epithelial malignancy of the kidney in adults and accounts for approximately......
GIPC2,a novel tumor suppressor gene in pheochromocytoma,activates the expression of p27 through NONO
GIPC2 is a member of the GIPC family which regulates various cellular processes,including proliferation,cytoplasmic divi......
The aberrant expression of microRNAs (miRNAs) plays roles in development, progression, metastasis and prognosis.MiR-1188......
Chromatin remodeling gene AT-rich interactive domain-containing protein 1A (ARID1A) encodes BAF250a protein,a noncatalyt......
Epigenetic activating of HKDC1 by Histone demethylase JMJD3 disrupts spectrin-dependent cytoskeleton
Objective Pancreatic ductal adenocarcinoma(PDAC)is still one of the most devastating cancers without effective therapeut......
.An increasing body of evidence suggested that downregulation or deletion of HECT domain and ankyrin repeat containing E......
lncRNA LSAT1 suppressed melanoma cell metastasis and invasion negatively regulated by hypoxia-induce
Long non-coding RNAs (lncRNAs) are emerging as new regulators in the cancer paradigm,demonstrating potential roles in bo......
Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promo
Purposes: To identify tumor suppressor genes (TSGs) silenced by aberrant promoter methylation and discover new epigeneti......
The epigenetic silencing of tumor suppressor gene PAX5 is involved in tumorigenesis of human non-sma
Aim: Recent studies have suggested that the paired box 5 (PAX5) gene is connected with tumorigenesis of a wide variety o......
OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT v
PURPOSE:Emerging evidence has indicated that the expression of opioid binding protein/cell adhesion molecule-like (OPCML......
H3K27 Trimethylation is an Early Epigenetic Event of p16NK4a Silencing for Regaining Tumorigenesis i
Stable epigenetic silencing of p16INK4ais a common event in hepatocellular carcinoma (HCC) cells,which is associated wit......
Tumor suppressor p53 restricts the proliferation of abnormal or DNA-damaged cells by regulating the expression of variou......
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A genome-wide allelotype study of primary and corresponding recurrent glioblastoma multiforme in one
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Human tumor suppressor hTid1-S, regulates AMPKmTOR signaling to suppress cell renal cell carcinoma p
Renal cell carcinoma (RCC) is the most common epithelial malignancy of the kidney in adults and accounts for approximate......
生长抑制因子（ ING）家族是候选的抑癌基因，ING4基因是该家族的新成员。 ING4基因在正常组织中表达丰富，在胃癌、结直肠癌、肝细胞癌、......
人类Klotho基因位于染色体13q12区域，全长约50 kb。 Klotho基因敲除小鼠表现出多种类似人类衰老的相关表型，并且与肿瘤抑制作用密切......
Targeting androgens via androgen deprivation therapy (ADT) to sup-press androgens/androgen receptor (AR) functions remai......
目的 探究肾母细胞瘤组织中具有磷酸酶活性的抑癌基因PTEN及肿瘤抑制因子PDCD4 mRNA和蛋白表达及其临床病理联系。方法 采用RT-PCR......
目的构建NKX3.1真核表达载体，探讨NKX3.1的基因定位以及其对前列腺癌细胞株PC3细胞周期和凋亡的影响。方法利用PCR技术从正常人前列......
自噬与卵巢癌的发生、发展及药物耐药相关，已成为卵巢癌研究的热点。诸多学者认为抑癌基因与癌症关系密切，而一些常见抑癌基因与自噬......
Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastri
AIM: To investigate the rrelationship between methylation of Syk (spleen tyrosine kinase) gene in promoter region and on......
目的 观察感染Ad5-KAI1前后人胰腺癌细胞MiaPaCa-2自噬水平的变化,并初步探讨其机制.方法 应用无KAI1表达的人胰腺癌细胞MiaPaCa2,......
Genetic and epigenetic changes associated with cholangiocarcinoma: From DNA methylation to microRNAs
Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little i......
Background:To identify PTEN isoform and explore its potential role in tumor suppression.Methods:Western blotting,over-ex......
FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion
Objective:Growing evidence indicates that FAT atypical cadherin 1 (FAT1) has aberrant genetic alterations and exhibits p......
[目的]探讨P16、Ki-67蛋白在宫颈上皮内瘤样变(CIN)组织中的表达及其意义.[方法]收集本院2013年1月至2016年1月收治的96例疑诊为CI......
背景:前列腺癌是全球最常被诊断的癌症之一,并且是美国男性因癌症死亡的第二大病因。与白人男子相比,非洲男子更容易出现前列腺癌......
目的 探讨转染Kiss-1基因对人黑色素瘤细胞A375生长增殖的影响,筛选出有意义的肿瘤治疗的生物学靶标.方法 在人黑色素瘤细胞A375中......
目的 研究抑癌基因WWOX对卵巢上皮性癌(卵巢癌)细胞生长的影响,寻求卵巢癌基因治疗的新途径.方法 将携有WWOX基因的真核表达载体体......
目的 研究第10染色体同源丢失性磷酸酶-张力蛋白基因(PTEN)对胰腺癌细胞系ASPC-1细胞周期、细胞增殖、血管内皮生长因子(VEGF)和表......
视网膜母细胞瘤蛋白质结合的锌指蛋白1( RIZ1)是一种甲基转移酶,其功能单位为特征性的PR锌指结构域.RIZ1能够通过PR结构域甲基化组......
人类3号染色体短臂(3p)上抑癌基因的异常改变(如缺失突变、转录失活或沉默等)被认为是包括肾癌尤其是肾透明细胞癌在内的人类多种......
目的 探讨乳腺癌转移抑制基因1( BRMS1)在结肠癌组织中的表达及其意义.方法 采用免疫组化二步法,检测46例结肠癌组织及癌旁组织中B......
甲基化特异性聚合酶链反应(MSP)技术检测DNA异常甲基化是一种极好的新方法....
